What is ADNFarma®?
ADNFarma® is a pharmacogenetics study, which studies the actions and interactions between drugs in each person at an individual level, based on their genome and their effects on gene expression, and can predict the efficacy and toxicity of drugs, thus allowing the application of the ideal therapy. Drugs can cause adverse reactions, resulting in significant morbidity, therapeutic failure and even mortality, as well as increased healthcare costs.
In this report we present the results of your ADNFarma® genetic analysis based on your genotype. The report contains information on genetic variants that we found in your genome that have been associated with drugs used to treat a number of common medical conditions.
In this comprehensive pharmacogenetic study we analyze genetic variants distributed in your 23 pairs of chromosomes that metabolize drugs of interest.
Do medications work best based on your metabolism?
When a drug is administered, a process of absorption, distribution, interaction with its substrate, metabolization and excretion is initiated. Each of these steps is mediated by the action of proteins in which variations may exist, resulting in different responses in each patient. The identification of the underlying genetic variations allows the most appropriate treatment to be prescribed in each case.
Please note that the results of this genetic analysis do not contain information for all known genetic variants in the human genome. This is due to the fact that new variants associated with specific health conditions are continuously being discovered in research studies under development and to the constant discovery of new drugs that are not yet on the market. In this comprehensive pharmacogenetics study we analyze genetic variants distributed in your 23 pairs of chromosomes that metabolize drugs of interest.
What drugs are reported in ADNFarma®?
In addition to those of interest to the patient and the physician, an extensive list of drugs associated with different categories, from psychiatric, oncological to general/common use drugs, is annexed.
| Acenocoumarol | Dofetilide |
| Nebivolol | Aliskiren |
| Dronedarone | Nifedipine |
| Amiodarone | Eplerenone |
| Nisoldipine | Amlodipine |
| Flecainide | Prasugrel |
| Atorvastatin | Guanabenz |
| Pravastatin | Azilsartan |
| Hydralazine | Propafenone |
| Carvedilol | Hydrochlorothiazide |
| Propranolol | Cerivastatin |
| Isosorbide dinitrate | Ranolazine |
| Cilostazol | Labetalol |
| Rosuvastatin | Clonidine |
| Lidocaine | Simvastatin |
| Clopidogrel | Losartan |
| Ticagrelor | Diltiazem |
| Lovastatin | Timolol |
| Disopyramide | Metoprolol |
| Verapamil |
| Articaine | Cyclobenzaprine |
| Diclofenac | Dipyrone (Metamizole) |
| Epinephrine | Fentanyl |
| Hydrocodone | Ibuprofen |
| Keterolac | Meloxicam |
| Methadone | Oxycodone |
| Tramadol |
| Atazanavir | Fosamprenavir |
| Raltegravir | Boceprevir |
| Indinavir | Saquinavir |
| Darunavir | Itraconazole |
| Telaprevir | Dolutegravir |
| Nelfinavir | Telithromycin |
| Efavirenz | Nevirapine |
| Terbinafine | Erythromycin |
| Quinine Sulfate | Voriconazole |
| Apixaban | Avatrombopag |
| Eltrombopag | Lusutrombopag |
| Rivaroxaban | Warfarin |
| Aprepitant | Dexlansoprazole |
| Drospirenone | Esomeprazole |
| Lansoprazole | Metoclopramide |
| Omeprazole | Ondansetron |
| Palonosetron | Pantoprazole |
| Rabeprazole |
| Amoxicillin | Clarithromycin |
| Clindamycin |
| Alprazolam | Doxepin |
| Paroxetine | Amitriptyline |
| Duloxetine | Perphenazine |
| Amoxapine | Escitalopram |
| Pimozide | Amphetamine |
| Fluoxetine | Pitolisant |
| Aripiprazole | Fluvoxamine |
| Protriptyline | Atomoxetine |
| Haloperidol | Quetiapine |
| Brexpiprazole | Iloperidone |
| Risperidone | Bupropion |
| Imipramine | Sertraline |
| Buspirone | Lorazepam |
| Thioridazine | Cariprazine |
| Midazolam | Trazodone |
| Citalopram | Mirtazapine |
| Trimipramine | Clomipramine |
| Nefazodone | Venlafaxine |
| Clonazepam | Nicotine |
| Vortioxetine | Clozapine |
| Nortriptyline | Ziprasidone |
| Desipramine | Olanzapine |
| Zuclopenthixol | Desvenlafaxine |
| Oxazepam | Valproic Acid (Sodium Valproate) |
| Diazepam | Paliperidone |
| Elagolix | Ethinyl estradiol |
| Flibanserin | Sex hormones and modulators of the genital system |
| Ospemifene |
| Arformoterol | Dexamethasone |
| Fluticasone | Formoterol |
| Indacaterol | Isoniazid |
| Salmeterol | Sildenafil |
| Tadalafil | Tiotropium |
| Umeclidinium |
| Sirolimus |
| Darifenacin | Fesoterodine |
| Finasteride | Mirabegron |
| Oxybutynin | Tamsulosin |
| Tolterodine | Vardenafil |
| Chlorpropamide | Glimepiride |
| Glyburide | Nateglinide |
| Tolbutamide |
| Amifampridine | Dextromethorphan |
| Meclizine | Brivaracetam |
| Donepezil | Phenytoin |
| Cafergot | Eletriptan |
| Quinidine | Clobazam |
| Galantamine | Tetrabenazine |
| Deutetrabenazine | Lacosamide |
| Valbenazine |
| Axitinib | Erdafitinib |
| Paclitaxel | Belinostat |
| Erlotinib | Pazopanib |
| Binimetinib | Etoposide |
| Rucaparib | Bosutinib monohydrate |
| Exemestane | Sorafenib |
| Brentuximab vedotin | Fluorouracil |
| Sunitinib | Cabazitaxel |
| Gefitinib | Tamoxifen |
| Capecitabin | Ibrutinib |
| Tegafur | Cisplatin |
| Irinotecan | Temsirolimus |
| Dasatinib | Lapatinib |
| Thioguanine | Docetaxel |
| Mercaptopurine | Tropisetron |
| Dolasetron | Methotrexate |
| Vemurafenib | Enzalutamide |
| Nilotinib | Vincristine |
| Azathioprine | Carisoprodol |
| Celecoxib | Cyclosporine |
| Everolimus | Flurbiprofen |
| Lesinurad | Pyroxicam |
| Siponimod | Sirolimus |
| Tacrolimus |
| Cevimeline | Colchicine |
| Tofacitinib |
| Atovaquene | Codeine |
| Eliglustat | Eszopiclone |
| Hydroxychloroquine | Lofexidine |
| Loratadine | Modafinil |
| Tafenoquine | Triazolam |
| Zolpidem |
What genes do we analyze at ADNFarma®?
We analyzed more than 24 genes and 106 variants directly involved in drug metabolism, the most important being cytochromes (CYP). Thus describing by category your metabolic capabilities (ultra-fast, normal, intermediate and poor).
Cytochrome P-450 enzyme plays an extremely important role in the toxicological elimination metabolism of drugs from the body. Some of these reactions are of great physiological importance, as they are key transformations in metabolism, such as lipid metabolism and corticosteroid biosynthesis. More than 53 cytochrome P-450 enzymes are found in humans. These enzymes are promiscuously molecularly active due to the diversity of reactions they catalyze.
Due to the importance of this enzyme in GenoLife DNA, we took the 8 most important genes associated with the metabolism of this enzyme which are; CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, in which we analyzed more than 40 variants only for this metabolism.
ADNFarma®: Meet an alternative for your Oncological and Psychiatric treatments
Due to the complexity and inaccuracy of psychiatric treatments derived from different environmental factors that may influence human behavior, as well as the varied and expensive cancer treatments, at GenoLife we have taken on the task of helping you choose more accurately through the ADNFarma® molecular study.
How do we conduct your ADNFarma® study?
Using only a small swab of saliva from the patient's mouth, we can give you access to your DNA information.
DNA is analyzed with a microarray and qPCR for the analysis of variants of interest. The interpretation of the genetic variants has been performed by Genolife Información de Vida.
At GENOLIFE we are seriously committed to your health and we apply the most advanced technologies for genetic studies.
How will I see my results in ADNFarma®?
Download a sample report!
ADNLIFE
- Customized report
- Appointment with an interpreter